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To ensure the integrity of the genome and hence the fitness and viability of cells, DNA lesions that are formed as a result of various toxic assaults are normally repaired by an elaborate network of DNA damage response (DDR) pathways. Interestingly, DNA is also the main target of most chemotherapeutic agents and ionizing radiations, two key components of anti-cancer therapy. GRCC has contributed to elucidating DNA repair pathways and their abnormalities for over 30 years. SOCRATE 2.0 will focus on better understanding the crosstalk between DNA damage, DNA damage response pathways and inflammation, in order to design new diagnostic, prognostic, and therapeutic strategies for chemotherapy, radiotherapy, DNA damage/DDR- associated targeted therapies.